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Indications and Dosage
Ophthalmic
Diagnostic agent for the measurement of intraocular pressure by Goldmann tonometry Adult: Lidocaine 4% w/v and fluorescein 0.25% w/v eye drop solution
Instil 1 or more drops, as required. |
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Contraindications
Hypersensitivity to lidocaine, fluorescein, and other amide-type local anaesthetics.
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Special Precautions
Patient with an inflamed eye (as it may increase the systemic absorption through the conjunctiva). Elderly. Pregnancy and lactation.
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Adverse Reactions
Significant: Blurred vision, corneal inflammation (prolonged use).
Eye disorders: Allergic conjunctivitis, periorbital oedema. Immune system disorders: Anaphylactic reactions. Skin and subcutaneous tissue disorders: Urticaria, rash. |
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Patient Counseling Information
This drug may cause blurred vision which may impair visual acuity, if affected, do not drive or operate machinery. Protect the anaesthetised eye from foreign body contamination, particularly in the elderly whose duration of anaesthesia may be >30 minutes. To minimise systemic absorption, may compress the lacrimal sac at the medial canthus for 1 minute after instillation.
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Action
Description:
Mechanism of Action: Lidocaine is an amide-type local anaesthetic agent that blocks the sensory nerve endings of the cornea. Fluorescein is a fluoresce dye that stains damaged or abraded cornea, disrupted ocular fluids, and foreign bodies. It is used to detect corneal lesions and foreign bodies and as an aid in various diagnostic ophthalmic procedures. Synonym(s): Lidocaine: Lignocaine. Pharmacokinetics: Distribution: Enters breast milk. Lidocaine: Crosses the placenta. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 3676, Lidocaine. https://pubchem.ncbi.nlm.nih.gov/compound/Lidocaine. Accessed Dec. 20, 2023.  Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 16850, Fluorescein. https://pubchem.ncbi.nlm.nih.gov/compound/Fluorescein. Accessed Dec. 20, 2023. |
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Storage
Store between 2-25°C. Do not freeze. Protect from light. Storage recommendations may vary between countries (refer to detailed local product guidelines).
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MIMS Class
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References
Anon. Fluorescein. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 27/09/2023. Anon. Lidocaine (Ophthalmic). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 27/09/2023. Anon. Lidocaine and Fluorescein. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 27/09/2023. Bausch & Lomb (NZ) Ltd. Minims Lidocaine & Fluorescein Eye Drops Solution data sheet 30 November 2018. Medsafe. http://www.medsafe.govt.nz. Accessed 27/09/2023. Buckingham R (ed). Fluorescein. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/12/2023. Buckingham R (ed). Lidocaine. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 27/09/2023. Joint Formulary Committee. Fluorescein with Lidocaine. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 13/12/2023. Minims Lidocaine & Fluorescein (Bausch & Lomb UK Limited). MHRA. https://products.mhra.gov.uk. Accessed 27/09/2023.
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